The University of Southern Mississippi's Gulf Coast Research Laboratory (GCRL) located in Ocean Springs is a pivotal marine science hub and a key component of the University. Spanning 275 acres over two sites, GCRL stands out as one of the largest marine laboratories in the southeastern United States. Its prime location on the Mississippi Gulf Coast affords exceptional access to the Gulf of Mexico, ideal for cutting-edge research and fieldwork. This proximity facilitates specialized research in areas such as coastal ecology, aquatic health, fisheries, and marine aquaculture.

GCRL is renowned for its integration of research and education, offering a dynamic learning environment within its state-of-the-art facilities. The laboratory houses the Division of Coastal Sciences, the Center for Fisheries Research and Development, the Marine Education Center, and the Thad Cochran Marine Aquaculture Center. Students and researchers benefit from access to research vessels, providing hands-on learning experiences and unique field-based research opportunities. While not a standalone campus like USM's Hattiesburg or Long Beach locations, the lab plays a crucial role in advancing the University's educational and research missions, particularly in marine science and coastal studies.