South Louisiana Community College (SoLAcc) – Opelousas, situated at 332 East South St. in Opelousas, Louisiana, plays a crucial role within the SoLAcc network by offering a blend of technical training and associate degree programs to students in St. Landry Parish. This campus, also known as the T.H. Harris Campus, hosts one of the largest Practical Nursing programs in the region, equipping students to become Licensed Practical Nurses ready to serve in various healthcare settings. A standout feature of the Opelousas campus is its Nondestructive Testing program, the only one in Louisiana that is accredited, which prepares inspectors for diverse industries.

Moreover, the campus fosters an engaging student life environment through initiatives that encourage networking, leadership, community service, and cultural exploration. Academically, it provides programs in Diesel Powered Equipment Technology, Electrician, Industrial Electronics Technology, Medical Assistant, and Welding, among others. The campus upholds SoLAcc's mission of transforming lives and communities through quality education. It also supports online programs in fields like Business and Criminal Justice, enhancing educational access and flexibility for its student body. Through strategic partnerships, including initiatives such as the free CDL training program for Black men, the Opelousas campus actively contributes to the social and economic development of the local community.