Collin College's McKinney campus, the original branch established in 1986, is a vital part of the college system, offering a robust educational experience. The campus is home to the prestigious Cary A. Israel Health Sciences Center, a top-of-the-line facility that supports renowned Health Sciences and Nursing programs. Students can pursue various healthcare programs, including Licensed Vocational Nursing (LVN), Associate Degree Nursing (ADN), and Bachelor of Science in Nursing (BSN), alongside other diverse health science programs. Beyond healthcare, the campus also provides Associate in Arts (AA) and Associate in Science (AS) degrees, which are perfect for students interested in transfer or direct entry into the workforce.

Student life at McKinney is vibrant, centered around the Andrea-Mennen Welcome Center, which offers essential services such as career counseling, academic advising, admissions, and financial aid. The campus is well-equipped with resources like the Anthony Peterson Center for Academic Assistance and a comprehensive library, both designed to support student learning. Known for its supportive and engaging learning environment, the campus features cutting-edge facilities and current industry technology. This commitment to excellence is reflected in Collin College’s service to over 60,000 students annually, with more than 200 degrees and certificates available, making it an integral educational institution in the region.