Neosho County Community College's Ottawa campus, located in Ottawa, Kansas, offers a vibrant educational atmosphere with a focus on flexibility and accessibility. Established in 1991, the campus is nestled in a city of approximately 12,000 residents, providing convenient access to Lawrence and Kansas City. It caters primarily to part-time and non-traditional learners through extensive block scheduling and weekend classes, making higher education accessible to adult learners and those with non-traditional schedules. Despite its focus on flexibility, the Ottawa campus also serves many traditional students, creating a diverse learning environment.

The Ottawa campus is known for offering a variety of associate degrees and certificate programs, with popular options in vocational fields such as nursing and medical assisting. Notably, Ottawa High School students often participate in dual-credit courses through this campus, enhancing their educational experience. Although the campus does not offer on-campus housing like the main Chanute campus, it benefits from the broader resources and support systems of the NCCC network, including online learning opportunities and student services. With a student population of approximately 750 each semester, the Ottawa campus stands as a cost-effective and valuable educational resource, particularly given NCCC's reputation for having some of the lowest tuition rates in the state.