Mississippi Gulf Coast Community College's Perkinston campus, located at 51 Main Street in Perkinston, Mississippi, is an integral part of the college's legacy since its inception in 1912 as the Harrison County Agricultural High School 112. It uniquely features on-campus dormitories, providing students with a distinctive residential college experience. The campus offers a diverse range of academic and career-technical programs supported by robust fine arts, athletics, and a variety of student organizations, enabling a vibrant campus life 8.

Among its many facilities, the Perkinston campus includes modern resources like the Willis H. Lott Learning Resource Center, the Early Childhood Education Technology Building, as well as historically significant buildings such as Huff Hall, dating back to 1911, and the Gregory War Memorial Chapel, completed in 1947 1. Positioned conveniently on U.S. Highway 49, it affords students ready access to surrounding regions, enhancing their cultural and social opportunities. The campus emphasizes student success through small class sizes and personalized attention from faculty, along with essential support services like financial aid, career counseling, and housing 27. Athletic facilities such as the A.L. May Memorial Stadium and a baseball/softball complex further enrich the student life experience 1, making it a cornerstone of the college's mission to deliver a comprehensive and engaging education.