Lake Erie College of Osteopathic Medicine (LECOM) at Seton Hill, located in Greensburg, Pennsylvania, is an integral campus of the renowned LECOM system. It uniquely offers a Doctor of Osteopathic Medicine (D.O.) program within the supportive environment of the Seton Hill University campus. The focus is on the Problem-Based Learning (PBL) pathway, emphasizing student-centered learning through interactive small group discussions that are faculty-facilitated. The campus is well-equipped with specialized facilities, including PBL classrooms, an osteopathic practice lab, a lecture hall, and a medical library, enhancing the academic experience.

Students at LECOM Greensburg benefit from both the dedicated resources of the medical school and the shared amenities of Seton Hill University, such as dining and athletic facilities. Opportunities for clinical training are rich and varied, thanks to partnerships with healthcare systems like Allegheny Health Network and Conemaugh Health System. Additionally, the campus offers the Accelerated Physician Assistant Pathway (APAP) for certified physician assistants aiming to achieve a D.O. degree. This branch provides a harmonious balance of small-town ambiance with access to the urban attractions and scenic landscapes of the Laurel Highlands.