Keiser University's Port St. Lucie campus, situated at 9400 SW Discovery Way, is recognized for its diverse array of academic offerings, including both undergraduate and graduate degree programs. The campus is known for its strong emphasis on fields such as nursing, radiology, dietetics, and information technology, aligning with industry demands for professionals in biotechnology, business, computer graphics, and video game design. Featuring state-of-the-art facilities, students enjoy access to modern classrooms, well-equipped computer and medical labs, and a library filled with internet-enabled workstations. The cozy lounge area and ample parking make daily campus activities more comfortable and efficient.

Learning at Keiser University is interactive and hands-on, with an instructional approach that fosters more personalized attention due to small class sizes. The supportive faculty and numerous student resources contribute significantly to the school’s strong post-graduation employment rates, as many graduates secure positions within their chosen fields. While some students express concerns over tuition costs and communication issues, the overall experience is deemed challenging yet fulfilling. Although on-campus dining is limited, the school's location makes it easily accessible, providing a vibrant and nurturing setting for academic growth and professional preparation.