Howard College-San Angelo, situated at 3501 US Highway 67 in San Angelo, Texas, is a vital part of the Howard College system. This branch has a rich history, beginning in 1973 with its inaugural class at Goodfellow Air Force Base. Over the years, it has expanded significantly, notably integrating a vocational nursing program in 1981 from the San Angelo Independent School District. This expansion included the introduction of courses in real estate and law enforcement, broadening the college's academic offerings.

In 2001, the campus moved to the West Texas Training Center, marking a significant milestone in its growth. Further expansion of health profession programs took place in 2009 at St. John’s Hospital, reflecting the college’s commitment to providing comprehensive education in this field. As an open-admission institution, Howard College-San Angelo offers a variety of associate degrees and certificates, focusing on career technical and workforce education. These programs are designed to deliver quality education and support the diverse needs of its student community. Overall, the college fosters a thriving educational environment accented by ample student services and convenient accessibility for learners in the San Angelo region.