Collin College's Plano campus, known as the Spring Creek Campus, creates a dynamic and diverse learning environment. As the largest campus in the district by student population, it stands out with its thriving visual and performing arts programs. Noteworthy facilities include a 30,000-square-foot art gallery and the John Anthony Theatre, which accommodates 350 seats. Students can also engage in athletics, taking advantage of the competition basketball gym and Brinker Tennis Center. Additionally, it uniquely offers the district's only on-campus housing option, providing an appealing residential experience.

Academically, the campus presents a variety of programs like fine arts, insurance management, biotechnology, and medical assisting. Student life here is vibrant, supported by numerous clubs and activities that foster a supportive and engaging community. The campus is home to an 88,000-square-foot library, a stunning architectural piece inspired by Thomas Jefferson, further enriching the academic landscape. Core support services, such as academic advising and tutoring centers, are readily available to ensure student success. The campus's strategic location in Plano offers students easy access to off-campus amenities and experiences, making it an exceptional place to advance one's educational path.